Endocrine Abstracts

Currently, no effective medical therapy exists for inoperable phaeochromocytomas (PCCs). Thus, we investigated the antitumor potential of the dual PI3K/mTOR inhibitor NVP-BEZ235 against PCC in vivo. We employed a spontaneous model of endogenous aggressive PCCs (MENX rats), which closely recapitulate the human tumours. Administration of NVP-BEZ235 to MENX rats for 14 days inhibited proliferation (assessed by Ki67, NuSAP staining), vascularity (CD31, VEGFA), and induced...

Phaeochromocytomas (PCs) are neuroendocrine tumors derived from neural crest-derived chromaffin cells of the adrenal medulla and sympathetic ganglia.About 10% of all PCs can be malignant.Currently, there is no effective therapy for malignant PCs.In many neuroendocrine tumors, including PCs, the PI3K/AKT/mTOR survival pathway is hyperactivated. Therefore, the inhibition of this signaling cascade may exert an a...

Phaeochromocytomas (PCs) are neuroendocrine tumors derived from neural crest-derived chromaffin cells of the adrenal medulla and sympathetic ganglia (the latter referred to as paragangliomas), which produce significant amounts of catecholamines. Although PCs are mostly benign, 10% of all PCs can be malignant evidenced by the presence of metastases, predominantly in bone, lungs, liver and lymph. Currently, there is no effective therapy for malignant PCs.I...